COMBINED LIPIDOMIC AND PROTEOMIC ANALYSIS OF ISOLATED HUMAN ISLETS EXPOSED TO PALMITATE REVEALS TIME-DEPENDENT CHANGES IN INSULIN SECRETION AND LIPID METABOLISM.

Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism.

Studies on the pathophysiology of type 2 diabetes mellitus (T2DM) have linked the accumulation Polish of lipid metabolites to the development of beta-cell dysfunction and impaired insulin secretion.In most in vitro models of T2DM, rodent islets or beta-cell lines are used and typically focus is on specific cellular pathways or organs.Our aim was to

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OVERVIEW OF RUSSIAN CIVIL JUSTICE

Contemporary Russian civil procedure is not a pure Continental model because it also has Pop-ups procedural features of the common law system, as well as some other original and exceptional features.This article examines the main aspects of Russian civil justice: its main principles; judicial organization, including the structure of the courts and

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